Corresponding to the extensive interference of IFN production by SARS-CoV-2-encoded proteins, patients with COVID-19 usually exhibited a delayed type-I IFN response [90], i.e., IFN production was inhibited at the early stage of SARS-CoV-2 infection, which allows the virus to achieve successful replication in the host cells, undermining the asymptomatic infection. Here, IFNA1 is linked to COVID-19.