Interestingly, several SARS-CoV-2 proteins (3CLpro, ORF3a, and ORF9) were also able to target STING to regulate the IFN response [97], likely indicating a complex feedback interaction between SARS-CoV-2 and the innate immunity, and therefore a well-balanced immune interference targeting IFN response is required for COVID-19 therapy. This evidence concerns the gene IFNA1 and COVID-19.