MYC and leukemia: As previously demonstrated [38, 39], the mean of LPC frequency in Myc-derived T-ALL was 1 in 105 cells (95% CI: 1:77–165), whereas in Myc + IL7Rmut leukemias it was significantly higher (p = 0.0002, ELDA analysis), with 1 LPC in 11 cells (95% CI: 1:6–97; Fig. 5C and Supplementary Table 4).