Specifically, one-cell stage Tu/AB-strain embryos were micro-injected with rag2:Myc + rag2:mCherry alone or in combination with rag2:mut2 or another type 1a IL7R gain-of-function mutation (mut1, p.L242_L243insNPC) found in a different T-ALL patient [24]. The gene discussed is RAG2; the disease is acute lymphoblastic leukemia.