In agreement, we observed hyperactivation of IL-7R-mediated signaling in mutant IL7R leukemias, as evidenced by upregulation of phosphorylation levels of STAT5, Akt and S6 (a downstream target of PI3K/Akt/mTOR pathway), and Erk 1 and 2 (Fig. 1D). The gene discussed is AKT1; the disease is leukemia.