TET2 and congenital bilateral aplasia of vas deferens from CFTR mutation: Moreover, another study demonstrated that monocytes of patients with severe degenerative aortic valve stenosis or chronic postischemic heart failure, who harbour DNMT3A or TET2 CHDM, appeared to be primed for excessive inflammatory responses by assessing the transcriptome of circulating peripheral monocytes of CAVD by single-cell RNA sequencing [2].