In line with the data suggesting that PP-007 improves the resolution of the CF lung hyperinflammatory response caused by LPS treatment, the BALF concentrations of the immunomodulatory cytokines IL-6, IL-17, IL-12p70 and IP-10 were lower in PP-007-treated CF mice than in vehicle-treated CF control mice and comparable to those in vehicle-treated WT mice at 24 h post-LPS exposure (Fig. 5h and Supplementary Fig. 4d). This evidence concerns the gene CXCL10 and cystic fibrosis.