To test whether the PP-007-mediated induction of HO-1 in monocytes/MΦs is responsible for the reduction in lung inflammation induced by LPS, which we reported in CF mice (Fig. 5), HO-1Cx3Cr1 mice were pretreated with PP-007 or vehicle alone for 6 h and then nebulized with PA-LPS. This evidence concerns the gene HMOX1 and cystic fibrosis.