Similar to observations in CF-KO mice, PP-007 treatment was efficient in reducing the levels of lung neutrophils and BALF proinflammatory cytokines (i.e., IL-6, IL-17, IL-12p70, and IP-10) in βENaC-Tg mice exposed to LPS (Supplementary Fig. 5a–c). This evidence concerns the gene CXCL10 and cystic fibrosis.