These include glomerulonephritis with immune deposits (antiglomerular basement membrane (GBM) disease, and membranous glomerulonephritis, where there are glomerular IgG and C3 deposits); and Focal and Segmental glomerulosclerosis (FSGS) where there are often glomerular IgM and C3 deposits); and in glomerulonephritis where immune deposits are less common (antineutrophil cytoplasmic antibody (ANCA)-associated small vessel vasculitis, and minimal change glomerulonephritis). The gene discussed is C3; the disease is membranous glomerulonephritis.