SH3PXD2A and orofacial cleft: The SH3PXD2A gene was studied in mouse and humans defining it as a potential risk gene for orofacial clefting, indeed, Cejudo-Martin et al.91 argued that disruption of the mouse SH3PXD2A gene was associated with complete cleft of the secondary palate in 50–90% of mutant mice.