In a GBTM analysis, we divided the 236 patients by pattern of Hb variation into 4 groups: elevated Hb (11 patients, 4.7%), stable Hb (110 patients, 46.6%), decreasing Hb (84 patients, 35.6%), and persistent anemia (31 patients, 13.1%) groups (indicated in black, blue, green, and red, respectively, in Fig. 4B, C). Here, GSTM1 is linked to anemia (phenotype).