By comparing the expression level of 22 m6A regulator genes in tumors with adjacent normal tissues, these seven genes were down-expression in tumor tissues: ZCCH4 (Fig. 4A), METTL3 (Fig. 4B), ZC3H13 (Fig. 4H), YTHDC1 (Fig. 4J), YTHDC2 (Fig. 4M), METTL16 (Fig. 4O), FTO (Fig. 4U), while those nine genes of HNRNPC (Fig. 4C), YTHDF1 (Fig. 4D), HNRNPA2B1 (Fig. 4F), IGF2BP1 (Fig. 4G), VIRMA(Fig. 4K), IGF2BP2 (Fig. 4P), YTHDF2 (Fig. 4Q), RBM15 (Fig. 4R), IGF2BP3 (Fig. 4V) were up-regulated in tumor tissues. The gene discussed is METTL16; the disease is neoplasm.