We next compared FUS cytoplasmic translocation following flavo treatment with the behavior of two other proteins, the ALS/FTD-associated RBP TDP-43 and a non-shuttling RBP, hnRNP C. Consistent with a previous study22, IF revealed that TDP-43 underwent substantial cytoplasmic translocation upon transcriptional inhibition (Fig. 1C,E). This evidence concerns the gene FUS and amyotrophic lateral sclerosis.