HR-PKS were divided in four clades: HR-PKS clade I (KS-AT-DH-(MT)-ER-KR-ACP), HR-PKS clade II (KS-AT-DH-(MT)-KR-ACP-(C)-(A)-(PCP)), HR-PKS clade III (KS-AT-DH-ER-KR-PP-(PP)), and HR-PKS clade IV (KS-AT-DH-MT-ER-KR-ACP). This evidence concerns the gene NDUFAB1 and tetrasomy 12p.