NR-PKS were divided in four clades: a clade basal to clades I and II ((SAT)-KS-AT-PT-ACP-(ACP)-(TE)), NR-PKS clade II (SAT-KS-AT-PT-ACP-ACP-TE), NR-PKS clade II (SAT-KS-AT-PT-ACP-ACP-TE) and NR-PKS clade III ((SAT)-KS-AT-ACP-(ACP)-MT-(TE)). This evidence concerns the gene F2 and tetrasomy 12p.