Fibrinogen has recently been proposed as one of the markers for silicosis50 and could be indicative of the evolution of the fibrotic process in the lungs of silicotic patients, but again, as occurs with ACE and LDH, fibrinogen on its own is not a specific marker for silicosis, and this circulating fibrinogen is elevated in patients with different types of fibrotic diseases51. The gene discussed is ACE; the disease is silicosis.