For instance, SLC16A1 and BSG, belonging to cluster 1 and playing vital roles in energy metabolism (Halestrap & Price, 1999; Felmlee et al, 2020), are up-regulated in a variety of cancer types (Fig S9B) and could promote tumor growth and aggressiveness through the Warburg effect (Vaupel & Multhoff, 2021). Here, BSG is linked to cancer.