IFNG and neoplasm: Cancer cells can evade CTLs by reducing tumor antigen presentation, and inefficient MHC-I induction by IFNγ in melanoma correlates with resistance to ICB therapy.4 Our analysis revealed that INHBA expression attenuated the levels of IFNγ protein in bulk tumors and in infiltrating CTLs, yet without altering MHC-I expression by tumor cells.