What’s more, these three members have already been proven to participate in some human cancers: ITPR1 in Sézary Syndrome and osteosarcoma [15, 16], ITPR2 in acute myeloid leukaemia and clear cell renal cell carcinoma [17, 18], ITPR3 in multiple cancers: cervical squamous cell carcinoma [19], glioblastoma [20], cholangiocarcinoma [21] and so on. Here, ITPR3 is linked to cholangiocarcinoma.