We also observed weak evidence of a causal effect of 1 SD increase in concentrations of MIP-1b (CCL4) (IVW: OR = 1.04 95% CI: 0.99 to 1.09, p = 0.08) and Eotaxin (IVW: OR = 1.08 95% CI: 0.99 to 1.17, p = 0.10) on risk of Alzheimer’s disease. This evidence concerns the gene CCL4 and early-onset autosomal dominant Alzheimer disease.