CCL4 and early-onset autosomal dominant Alzheimer disease: Xia et al. reported that receptors of MIP-1b (CCL4) were present on microglia and subpopulation of reactive astrocytes and neurons in brains of patients with Alzheimer’s disease compared to controls, thus they could potentially play a role in the progression of Alzheimer’s disease through glial-glial and glial-neuronal interactions (Xia et al., 1998).