A case-control study observed elevated levels of IL-8 in the CSF of Alzheimer’s disease patients compared to non-demented controls (Taipa et al., 2019), when another case-control study reported significantly lower levels in both serum and CSF of Alzheimer’s disease patients (Hesse et al., 2016). This evidence concerns the gene CXCL8 and early-onset autosomal dominant Alzheimer disease.