For IL-2, a detrimental causal effect on Alzheimer’s disease risk was observed (Wald Ratio: OR = 1.03 95% CI: 1.00 to 1.06, p = 0.04), although the effect estimate was much smaller in magnitude compared to analyses including only diagnosed cased of Alzheimer’s disease. The gene discussed is IL2; the disease is early-onset autosomal dominant Alzheimer disease.