Three major phenotypes according to gene polymorphisms (Hp1-1, Hp2-1, and Hp2-2), unprocessed precursors (proHp1 and proHp2), and unusually glycosylated Hp (especially fucosylated Hp) have been reported and they play diverse roles in inflammation, diabetic vascular disease, angiogenesis, and malignant tumors [19, 20, 24]. Here, HP is linked to cancer.