Immune response-related gene sets, such as IL2-STAT5 signaling, interferon (IFN)-α and IFN-γ responses, were significantly enriched in the high-score glioma group in TCGA, CGGA, and CGGA (array) datasets (Figure 5A, 5B, Supplementary Figure 5A), which confirmed that the angiogenesis pathway score was closely associated with the anti-glioma immune response. Here, IL2 is linked to central nervous system cancer.