TNF and central nervous system cancer: In addition, unfavorable gene sets including hypoxia, IL6-JAK-STAT3 signaling, inflammatory response, TGF-β signaling, and TNF-signaling via NFkB gene sets were also highly enriched in the high-score groups in the three datasets (Figure 5C–5D, Supplementary Figure 5B), which explained the poor prognosis of the high-score glioma group from the perspective of signaling pathways.