The results showed that PANC-1-EVhnRNPA1 rarely affected the infiltration of α-smooth muscle actin–positive (α-SMA–positive) CAFs and CD68-positive TAMs in the primary tumor as compared with the control (Figure 3, F–H, and Supplemental Figure 5, L–P), suggesting that EV-packaged hnRNPA1 directly triggered lymphangiogenesis of KRASG12D PDAC independent of the infiltrated cells, including CAFs and TAMs in the TME. Here, CD68 is linked to neoplasm.