KRAS and neoplasm: Given that EVs, the nanoscale carriers for communication between tumor cells and stromal cells, have been considered to mediate molecules crossing the extracellular matrix into lymphatic circulation (21), we isolated the EVs from the culture media of PDAC cells with different KRAS subtypes (KRASG12D: PANC-1, AsPC-1; KRASG12V: Capan-2; KRASG12C: Mia-PaCa-2; KRASWT: BxPC-3) to investigate whether hnRNPA1 exhibited its function in KRASG12D PDAC cell–secreted EVs.