HNRNPA1 and neoplasm: Since the TME of PDAC is accompanied with highly infiltrated cells, which release abundant EVs into the extracellular space of PDAC tissues, we also evaluated the expression of hnRNPA1 in EVs secreted by the predominant cells in the TME of PDAC, including fibroblasts, macrophages, T cells, and B cells, as well as the tumor cells.