We treated mice bearing H3255 or PC-9 tumor xenografts with osimertinib or vehicle and found that mice with tumors in which RBM10 was silenced had decreased osimertinib sensitivity compared with mice bearing shScr control–expressing tumors (Figure 3, A and B, and Supplemental Figure 3, C and D). The gene discussed is RBM10; the disease is neoplasm.