,53 Interestingly, about 70% of the α-SMA-positive cells in our analysis also expressed common myeloid signature markers, such as CD45 and HLA-DR, indicating a myeloid cell to myofibroblast transdifferentiation in PVR membranes, as recently described for renal fibrosis.54 This evidence concerns the gene ACTA1 and renal fibrosis.