miR-515-5p inhibits various cancer processes, for instance, it acts as a prostate cancer inhibitor by targeting TRIP13 [25], suppresses HCC migration as well as invasion via the IL6/JAK/STAT3 pathway [26], inhibits breast cancer cell proliferation, migration as well as invasion via the hsa_circ_0008039/miR-515-5p/CBX4 axis [27]. This evidence concerns the gene IL6 and hepatocellular carcinoma.