PML and viral infectious disease: The membrane-less property of PML-NBs facilitates the dynamic flux and interactions of PML-NB client molecules, which have been shown to be involved in a number of biological processes, including viral infection (Chelbi-Alix et al., 1995; Puvion-Dutilleul et al., 1995; Everett and Chelbi-Alix, 2007), DNA damage response (Louria-Hayon et al., 2003; Bernardi et al., 2004; Bøe et al., 2006), senescence (Ferbeyre et al., 2000; Pearson et al., 2000), and telomere recombination (Draskovic et al., 2009; Flynn et al., 2015).