In addition, the thyroid binding globulin (TBG) and ALB are mainly synthesized in the liver [16], liver failure may decreased the synthesis of TBG, the accelerated breakdown of TBG could lead to thyroid hormone-binding capacity decrease, then serum TT3 and TT4 levels were decrease, and FT3 would also decrease subsequently [9,17]. The gene discussed is ALB; the disease is Hepatic failure.