There was a lot of research showed the predictors of ACLF prognosis, including liver predictive factor (TB), kidney predictive factors (creatinine), brain predictive factor (HE), coagulation predictive factor (INR), circulation predictive factors (mean arterial pressure and vasopressor use) and thyroid hormone predictive factors (T3, T4, FT3, and TSH concentrations) [11–13]. The gene discussed is CD4; the disease is hereditary elliptocytosis.