The altered ECM landscape in liver cirrhosis include the upregulation of collagens (type I, III, IV, V, VI, VIII, X, XI, XII, XIV, XV, XVI, XVIII, XXI), proteoglycans such as versican, decorin, lumican, and glycoproteins including fibulins, fibronectin, and laminins (Dataset EV5). This evidence concerns the gene LAMB2 and cirrhosis of liver.