Membrane proteins with virus receptor activity involved in interspecies interaction were also highly enriched such as CD46, ICAM1, PVR (poliovirus receptor), EPHA2 (ephrin type‐A receptor 2, which acts as a HCV receptor in hepatocytes and facilities its entry), as well as ANPEP (also known as CD13), DPP4 (also known as CD26) which both have human coronavirus receptor activity (Peck et al, 2017; Sungnak et al, 2020; Tang et al, 2020), presumably rendering LSEC more sensitive or susceptible to viral infection or translocation through receptor‐mediated endocytosis or fusion. This evidence concerns the gene CD46 and viral infectious disease.