When extracting the most abundant proteins in liver biopsy based on intensity of LFQ, we found metabolic enzymes (carbamoyl‐phosphate synthase 1 (CPS1), which is heavily downregulated in NAFLD (De Chiara et al, 2018), alcohol dehydrogenase 1B (ADH1B), and retinaldehyde dehydrogenase 1 (ALDH1A1)), blood proteins (albumin (ALB) and hemoglobin subunits (HBA1, HBB)) and structural constituents of the cytoskeleton (vimentin (VIM), type VI collagen (COL6A3), myosin (MYH9), and keratin 18 (KRT18); Fig 2B). This evidence concerns the gene CPS1 and metabolic dysfunction-associated steatotic liver disease.