It should be mentionedthat amyloidosis is rather common in the elderly population18 and its associations with viral infections isa matter of discussion.13 Recent studiesdemonstrate that COVID-19 recovered patients have an increased riskof type II diabetes, an amyloid associated disease.28,29 While our study is limited to in vitro findingsof pure preparations of peptides and proteins, the results proposetaking S-protein amyloidogenesis into account when studying COVID-19and long COVID-19 symptoms. Here, PROS1 is linked to amyloidosis.