The ratio of chymase+:tryptase+ mast cells was significantly lower in asthmatic lamina propria compared with healthy lamina propria (p = 0.0022) (Figure S3I), but similar across asthma subgroups (Figure 2E), and demonstrated a gradient from the airway epithelium, through the lamina propria to the ASM in asthma (Kruskal–Wallis p = 0.0018) (Figure 2F). Here, CMA1 is linked to asthma.