As bronchoconstriction and mucus plugging are the predominant causes of airflow obstruction driving asthma symptoms, exacerbations and death, the factors that sustain these abnormal pathological features should be a priority for future research and drug development for severe asthma.Abbreviations: CCL, C‐C motif chemokine ligand; Eos, eosinophil; FeNO, fraction of exhaled nitric oxide; GC, goblet cell expressing MUC5AC; IL, interleukin; LTE4, leukotriene E4; MC, mast cell; Neu, neutrophil; T2, type2 cytokine; PGD2, prostaglandin D2; TSLP, thymic stromal lymphopoietin. Here, MUC5AC is linked to asthma.