HMGB1 blockade in the spinal cord also prevents tactile allodynia and thermal hyperalgesia of diabetic mice induced by STZ, which is related to the reduction of cytoplasmic HMGB1 expression and transport in the spinal dorsal root neurons (DRG)[18]. The above evidence suggests that HMGB1 is closely involved in pathogenesis of neuroinflammation and neurological diseases. Here, HMGB1 is linked to nervous system disorder.