The results of the association between levels of KIF22 protein expression and clinicopathological features revealed that a high level of KIF22 expression is associated with increased serum CA199 levels, a high Ki67 proliferation index, and a high stage, and these differences were statistically significant (Table 1, P < 0.05), but no statistically significant difference was found between the two groups in terms of age, gender, pathological type, differentiation, and status of lymph node metastasis (Table 1, P > 0.05). This evidence concerns the gene MKI67 and metastatic malignant neoplasm in the lymph nodes.