Further, the positive expression of ADPN, BDNF, SYN1, PSD95, and NMDAR1 significantly declined within the T2DM+Exe+RO8191 group in comparison with the T2DM+Exe+Vehicle group (P < 0.05, Figures 8(b), 8(c), 8(f), and 8(g)). Here, GRIN1 is linked to type 2 diabetes mellitus.