According to our results (Figure 5), the expression of FN1, COL1A1, and COL1A2 were downregulated in osteosarcoma and Ewing's sarcoma, which often act as oncogenes, suggesting that they were more likely to play roles of antioncogene in osteosarcoma and Ewing's sarcoma. The gene discussed is COL1A1; the disease is osteosarcoma.