Although studies have provided some insights into the oncogenic biological function of UBE2S, there is no comprehensive delineation regarding whether and how UBE2S determines oncogenesis, progression, and metastasis in various cancers, and therefore, a systematical pan-cancer analysis is warranted to elucidate the role of UBE2S in the immune-oncology context of TME, mutation burden, prognosis, and therapeutic response. The gene discussed is UBE2S; the disease is cancer.