In addition, we tried to delineate the key signaling pathways with respect to cancer development and progression and decipher the correlation between UBE2S expression and immune infiltration, immune evasion, genome instability markers, and therapeutic response, hoping that the results could provide novel insights into the essential immune-oncology properties of UBE2S in the field of cancer detection, prognosis, and therapeutic response prediction. The gene discussed is UBE2S; the disease is cancer.