HK2 and colonic neoplasm: As for colon cancer, miR-98 plays the role of tumor suppressor gene and inhibits Warburg effect by targeting HK2 (HK2 involves in miR-98-mediated suppression of glucose uptake, lactate production, and cell proliferation, whose expression was negatively correlated with miR-98) in colon cancer cells, which provided promising therapeutic candidate for clinical treatments [39].