Interestingly, downregulated genes in IBD are depleted in the IRF4, IRF8, and CEBPB’s target genes (Odds ratios are 0.45, 0.44, and 0.55, p-values are 5.61E−06, 2.03E−06, and 0.0037). The gene discussed is IRF8; the disease is inflammatory bowel disease.