CD274 and neoplasm: After discussion of the case in an interdisciplinary tumor board, a transoral CO2 laser resection of the supraglottic laryngeal cancer was recommended followed by a systemic treatment of the lung adenocarcinoma according to the KEYNOTE-186 protocol postoperatively, which represents the first-line treatment for non-squamous NSCLC with a PD-L1 TPS < 50% [10].