Therefore, to evaluate whether IL-13 polarization of microglia/macrophage to an anti-inflammatory phenotype mediates its protective effects after ischemic stroke, we stained mouse brains 3 days after tMCAO with the microglia/macrophages marker Iba1, the anti-inflammatory phenotypic marker CD206, or the pro-inflammatory phenotypic marker CD16 (Fig. 6B). The gene discussed is AIF1; the disease is ischemic stroke.