We also used the neuroblastoma SHSY5Y cell line to confirm our findings: both genes were significantly downregulated in the demethylated neuroblastoma cell line as well (PRKAR1B p = 6.33 × 10−05, HEATR2 3.37 × 10−06) (Fig. 4I, J). Here, PRKAR1B is linked to neuroblastoma.