SV2A and temporal lobe epilepsy: It has been well documented that mRNA level, protein expression, and specific radioligand binding density of SV2A are markedly decreased in the hippocampus and the anterior temporal neocortex of temporal lobe epilepsy (TLE) patients as revealed by real-time PCR, immunohistochemistry, western blot, and neuroimaging studies [14, 23–26].