Recently, it was found that extracellular vesicles derived from CRC could be specifically targeted to liver tissue and induce liver macrophage polarization toward an interleukin-6 (IL-6)-secreting proinflammatory phenotype through the miR-21/Toll-like receptor 7(TLR7)-IL6 axis [77]. Here, TLR7 is linked to colorectal carcinoma.