The elevated BMI as the main determinant of the insulinemic potential of lifestyle is a major effective factor in insulin metabolism and its related problems; because it has been reported that weight gain and adiposity are independently related to the risk of hyperinsulinemia, IR, and metabolic disorders [35], therefore, the remarkable part of the insulinemic effect of ELIH in increasing risk of obesity phenotypes can be caused by high BMI levels of participants. This evidence concerns the gene INS and metabolic disease.