In summary, we confirmed the expression of IL1-RL1 in asthma patients’ induced sputum supernatant, induced sputum cells and serum and found the correlation between its expression and type 1 and type 2 immune cytokines in patients with asthma, which provided new evidence for the involvement of IL1-RL1 in asthma. This evidence concerns the gene SGCG and asthma.