Mouse models with Ryr2 mutations (Ryr2R4496C, Ryr2N2386I, Ryr2A165D)20–23 and Casq2 mutations (Casq2D307H, Casq2DeltaE9/DeltaE9)24 can effectively replicate the CPVT phenotype. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.