REST and small cell lung carcinoma: Upon ectopic expression of REST in NE SCLC cells in culture, 99 and 205 genes were downregulated by RNA-seq after 48 h and 5 days, respectively, with corrected p-value < 0.05 and log2 fold change of <−1.0 (Fig. 2a, Supplementary Fig. 3e, f and Supplementary Data 4).