Intracellular neurofibrillary tangles (NFTs) constituting hyperphosphorylated tau proteins are a pathological hallmark of several neurodegenerative diseases including Alzheimer’s disease (AD)1, Pick’s disease, progressive supranuclear palsy, and corticobasal degeneration2, collectively called “tauopathies”. The gene discussed is MAPT; the disease is Alzheimer disease.