For instance, pseudophosphorylations (replacement of Ser and Thr residues by Glu residues) that reproduce AD-specific epitopes including AT8 (pSer202 and pThr205), AT100 (pThr212 and pSer214), and PHF-1 (pSer396 and pSer404) alone were able to induce tau monomer into the AD-specific conformation recognized by the conformational antibody MC-153. The gene discussed is PHF1; the disease is Alzheimer disease.