Out of the 31 sites found to be phosphorylated in both g-tau and s-tau, our LC-MS/MS result revealed that both combinations of kinases afforded tau phosphorylation in AD-specific epitopes, including targeting sites of AT8, AT180, AT100, and PHF-117 (Fig. 1c, Supplementary Fig. 1). This evidence concerns the gene MAPT and Alzheimer disease.