The signatures were not induced in other conditions where the disease triggers remain mysterious (e.g., sarcoidosis) or where the disease is driven by specific mutations, e.g., Neonatal onset multisystem inflammatory disease (NOMID) that is due to mutant NLRC3 and macrophage activation syndrome (MAS) that is due to mutant NLRC4). This evidence concerns the gene NLRC3 and macrophage activation syndrome.