The ViP/sViP signatures performed as anticipated in the negative and positive control datasets, i.e., neither signature was induced in immunosuppressed conditions, e.g., malignancies, pregnancy, post-transplant immunosuppression, but both were induced in infectious diseases, e.g., sepsis, HIV, RSV, and tuberculosis (left; Fig. 3d). The gene discussed is SVIP; the disease is cancer.