Several phenotypes have previously been explored with the goal of predicting future outcomes.39 To date, studies focusing on the potential role of NfL in predicting more severe progression phenotypes have suggested that patients with a more prominent postural instability phenotype have more substantial increases in NfL levels over time.16 17Our goal was to explore if NfL levels and /or genetic variables could play a role in a model which predicts PD progression in a more encompassing and practical manner that could potentially be utilised in disease modifying clinical trials. The gene discussed is NEFL; the disease is Postural instability.