UBQLN4 has been reported to function as a UBL-UBA protein (proteins that contain both a ubiquitin-like region and ubiquitin-associated domain) that stabilizes its target substrate, wild-type ataxin-1-(30Q).37 More importantly, UBQLN4 was significantly correlated with worse survival (figure 2G) and negatively correlated with activated CTLs and immune checkpoints in melanoma (figure 2H, online supplemental figure 3B). This evidence concerns the gene UBQLN4 and melanoma.