Moreover, ABZ-treated CD73 KO mice displayed a significantly greater reduction in tumor mass and weight than ABZ-treated or DMSO-treated WT mice and CD73 KO mice (figure 4F, G, J, K) without significant changes in body weight, the blood routine examination, the morphology of lung, liver, and spleen of mice in both melanoma B16F10 and LLC tumor-bearing immune-competent mouse models (online supplemental figure 4C–H). Here, NT5E is linked to neoplasm.