PTEN and Familial prostate cancer: Growth and metastatic capacity studies have also shown a positive correlation between PTEN and PTENP1 expression in normal human tissues, prostate cancer cell samples, and clinical samples of renal carcinoma, and a negative correlation with corresponding mRNA expression [4].Studies have also found that miR-30a and -b were downregulated in gastric cancer tissue samples and acted as tumor suppressors [38].