Tumor-intrinsic mechanisms include impaired tumor antigen presentation and loss of interferon sensitivity through loss-of-function alterations in the JAK/STAT signaling pathway (Gao et al., 2016; Garcia-Diaz et al., 2017; Gettinger et al., 2017; Grasso et al., 2018, 2020; Kalbasi et al., 2020; Manguso et al., 2017; Pan et al., 2018; Patel et al., 2017; Sade-Feldman et al., 2017; Shin et al., 2017; Zaretsky et al., 2016). Here, SOAT1 is linked to neoplasm.