One such PD-1-VEGFA-trap, AK112 (a humanized IgG1 bispecific anti-PD-1/VEGFA antibody), is currently being tested in multiple phase 2 clinical trials involving NSCLC, TNBC, and advanced gynecological tumors (NCT04736823, NCT05227664, NCT04870177). The gene discussed is PDCD1; the disease is female reproductive system neoplasm.