Instead of wound healing signatures, the microsatellite instability-high colorectal tumors (MSI CRC) are enriched with interferon gamma (IFN-γ)-related gene signatures; higher IFN-γ and lower wound healing signature enrichments were proposed to be the drivers of the ICB response in MSI CRC but not MSS CRC. The gene discussed is IFNG; the disease is colorectal neoplasm.