A subsequent review study showed that the rates of severe hypoglycemia in T2D were between 0.7 and 12 per 100 person-years in randomized controlled trials and between 0.2 (without treatment with insulin or sulfonylureas) and 2 (with treatment with insulin or sulfonylureas) per 100 person-years [7]. Here, INS is linked to type 2 diabetes mellitus.