SOD1 and Sepsis: Compared with those in the sepsis group, the levels of IL-6, IL-1β and TNF-α were increased (Fig 2A–2C, P < 0.05), the MDA content was increased, while the SOD and CAT activities were decreased in the sepsis + BAY 87–2243 group (Fig 2D–2F, P < 0.05).