Furthermore, the expression level of HIF-1α was lower in the sepsis + BAY 87–2243 group (Fig 4A and 4B; P < 0.05), and the protein expression levels of ZO-1, occludin and claudin-1 protein were significantly decreased (Fig 3A and 3C–3E and Table 1; P < 0.05). Here, CLDN1 is linked to Sepsis.