In this study, CAT and SOD activities in the plasma of rats with sepsis were significantly decreased, while the MDA content was significantly increase, indicating that a large number of oxygen free radicals had damaged the mucosal tissue and that the antioxidant system in the body had been exhausted and inhibited, which could be partially reversed by the up-regulation of HIF-1α after the treatment of DMOG; while the down-regulation of HIF-1α after the treatment of BAY 87–2243. The gene discussed is SOD1; the disease is Sepsis.