Hypoxia-inducible factor-1α (HIF-1α) is a key transcription factor through which the human body adapts to hypoxic environments and plays a key role in the acute hypoxia response [8], which is related to the pathophysiology of many major ischemic and hypoxic diseases and is known to be involved in sepsis and has already been proposed as both a marker and a therapeutic target of sepsis. This evidence concerns the gene HIF1A and Sepsis.