Compared with that in the sham group, the expression level of HIF-1α was significantly increased in the sepsis group (Fig 3A and 3B; P < 0.05), and the expression levels of ZO-1, occludin and claudin-1 were significantly decreased (Fig 4A and 4C–4E; P < 0.05). The gene discussed is CLDN1; the disease is Sepsis.