In this study, the expression of HIF-1α in the intestinal mucosa was significantly increased in septic rats compared to rats in the sham group, suggesting that sepsis caused intestinal mucosal cell hypoxia, and a compensatory increase in HIF-1α expression in the mucosal cells to improve the tolerance to hypoxia and promote proliferation, and maintain the integrity of the mucosal barrier. Here, HIF1A is linked to Sepsis.