Compared with the sepsis group, the sepsis + DMOG group exhibited significantly higher expression levels of HIF-1α and ZO-1, occludin and Claudin-1 in the intestinal mucosa (Fig 3A and 3B; P < 0.05) (Fig 3A and 3C–3E; P < 0.05). Here, HIF1A is linked to Sepsis.